对某患者静脉滴注利多卡因,已知:t1/2 =1.9h,V=100L,若要使稳态血

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问题 对某患者静脉滴注利多卡因,已知:t1/2 =1.9h,V=100L,若要使稳态血药浓度达到3μg/ml,则K0应为A.109.4μg/hB.109.4mg/hC.822.5μg/hD.822.5mg/hE.36.5mg/h

选项

答案B

解析根据静脉滴注稳态血药浓度的公式Css =k0 /kV,K0 =Css kV=3(0.693/1.9)×100000=109421μg/h=109.4mg/h。
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