已知大鼠口服蒿苯酯的Ka=1.905h^-1,k=0.182h^-1,V=4.2

书海库2020-05-20  10

问题 已知大鼠口服蒿苯酯的Ka=1.905h^-1,k=0.182h^-1,V=4.25L,F=0.80,如口服剂量为150mg,则AUC为A.155.14μg/(ml.h)B.14.82μg/(ml.b)C.193.92μg/(ml.h)D.26.66μg/(ml.h)E.155.14μg/(ml.h)

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答案A

解析血管外单室模型给药血药浓度-时间曲线下面积(AUC)计算公式:AUC=FX0 /kV=0.80×150×1000/0.182×4.25×1000=155.14μg/(ml.h)
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